Long-term supply of Ambisol, Anftek 13581980620 Ambisol price in the United States
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Long-term supply of Ambisol, Anftek 13581980620 Ambisol price in the United States
Details [Drug name] Ambisin Amphoteric [Common name] Amphotericin liposome for injection [English name] [Function and indications] Ambisin The indications for Amphotericin (liposomal amphotericin for injection) are: This product is suitable for patients with deep fungal infections who are unable to use effective doses of amphotericin due to kidney damage or drug toxicity or who have already received amphotericin treatment. It can be used by patients who are ineffective. [Usage and Dosage] For adults and children, it can be used at a dosage of .-.days according to requirements. If there is no improvement or the fungal infection worsens the dose may be increased to days. Dilute the dissolved product with % glucose injection and inject it intravenously at a rate of 1 hour. Before the first dose of each course of treatment, it is recommended to make a test injection with a small amount of medicine (the diluent contains .-.) and inject it for 1 minute. Watch carefully for another minute. If the patient can tolerate it and has no infusion-related reactions, the infusion time can be shortened to no less than 1 hour. If the patient has an acute reaction or cannot tolerate the volume infusion, the infusion time should be extended. Instructions for dissolving the drug and preparing the infusion solution This product must be dissolved in sterile water for injection. Use a sterile syringe and a needle of the following size and quickly add it into the bottle according to the following volume so that each solution contains amphotericin and gently use your hands. Shake and turn gently to dissolve all solids. Note that the liquid may be milky or clear. /Bottle with Sterile Water for Injection/Bottle with Sterile Water for Injection If used for infusion, further dilute the above dissolved liquid to a final concentration of approximately ./(.-./). The following table is a dilution recommendation: (only % glucose injection can be used for dilution) Dilution method Recommended dose of Avotex Avotex reconstitution volume % glucose infusion bag volume for injection Do not use saline or glucose solution to dissolve lyophilized powder and do not mix the dissolved solution with saline or electrolytes. The use of solutions other than those recommended above or the presence of biocides (i.e. benzyl alcohol) may cause precipitation of this product in the solution. Please do not filter or use an infusion set with a built-in filter when using this product. Do not mix infusion solutions with other medications. If through the infusion tube in use, flush the infusion tube with % glucose before administration or use a separate infusion tube. Injectable drugs should be inspected with the naked eye for foreign matter or discoloration before use. Do not use medicines that have sediment or foreign matter, or have problems with the seal of the original bottle. Since the lyophilized powder and the solutions used for dissolution and dilution do not contain preservatives, strict aseptic procedures must always be followed when preparing pharmaceutical solutions. After further dilution with % glucose injection, the solution must be stored at -°C and used within hours. Refrigeration is prohibited. Unused solution must be discarded. [Clinical Study] Aspergillus infection: This data is taken from an uncontrolled open study, one of which included emergency room patients with confirmed or suspected Aspergillus infection. The reason why the patients received this product was: No reaction to ordinary amphotericin () Nephrotoxicity when receiving ordinary amphotericin () Existing kidney damage () or other reasons (). The average age of the patients (male and female) was years (months to years). Median (%) neutrophils in patients with low levels of neutrophils[/[][/]. The total distribution of patients is: bone marrow transplantation (%), hematological tumors (%), solid organ transplantation (%), solid tumors (%), and other diseases (% including surgical cases, infection cases, autoimmune cases leading to immune Inhibition cases, diabetes cases and unknown disease cases). The lungs were the main site of infection in patients (%), followed by sinus site cases (%), central nervous system cases (%), skin/wound cases (%), and other cases (% including bone cases, liver cases, infectious cases, and one case each of endocarditis, ophthalmitis, otitis, and palatal disease). patients were treated for unresponsiveness to amphotericin, of whom 3 had received amphotericin within 2 days, 2 days before, and 3 days before receiving treatment with this product. These patients were determined to be ineffective by a physician based on comprehensive clinical indicators after receiving at least 10 days or a total dose of at least 1/2 of ordinary amphotericin. Nephrotoxicity means that the patient's serum creatinine is more than twice the basic level, that is, it increases ./d or increases to more than ./d. An increase in serum creatinine of ./d or greater due to reasons other than ordinary amphotericin is defined as pre-existing renal injury. The classification of diagnosis and effectiveness adopts the criteria proposed by the research group []. In this retrospective analysis, complete response refers to the disappearance of all relevant symptoms, features, cardiac abnormalities, etc. at the time of admission. Partial response is defined as a significant improvement in the above symptoms. The total number of responses is the sum of the above-mentioned completely response and partially response numbers. In this patient case, the dose was used for efficacy evaluation. Other cases were excluded due to inaccurate diagnosis, confusing condition, or use of less than or equal to 1 dose of this product. Among the patients available for efficacy evaluation, the average daily dose was days (.-.days), the average cumulative dose was (.-.days), and the average treatment time was days (-days). Response rate of evaluable patients []Total effective number = completely effective + partially effective, determined based on comprehensive clinical indicators after receiving at least days or total dose/of amphotericin treatment. [] is defined as a twofold increase in serum creatinine from the basic level, that is, an increase of ./d or an increase of ./d. [d] Defined as an increase in serum creatinine due to reasons other than amphotericin. /d Whether amphotericin treatment will be effective. Randomized comparative studies of the use of this product and amphotericin in the treatment of aspergillosis are ongoing. Renal function: Serum creatinine./d Some patients who started treatment with this product experienced a decrease in serum creatinine during treatment. Part of the reason may be that patients drop out of treatment during treatment. A medical history control was selected by reviewing medical records from year to year at each medical center (D. Cancer Center, Cancer Research Center at the University, Memorial Cancer Center at the University, and Bone Marrow Transplantation Research Center at the University). The mean value of serum creatinine was measured on the day when each patient's serum creatinine reached ./d. As shown in the figure, serum creatinine was lower in patients treated with amphotericin than in medical controls in patients receiving regular amphotericin. In the absence of a control group for direct comparison, it cannot be determined whether this reduction is significantly better than continued amphotericin. patients with deoxycholic acid. The above data were taken from two independent experiments and no statistical test was performed on the differences between them. The change curve of mean serum creatinine level over time in patients with Aspergillus infection and serum creatinine./d does not represent the clinical manifestations of a single patient but is only the unblinded result of a group of patients. [Precautions] This product should be administered intravenously. Acute reactions associated with infusion include fever, chills, hypotension, nausea, or tachycardia. These reactions usually occur within hours of starting the infusion. These reactions are more severe and frequent during the first few doses and then gradually disappear. Acute infusion-related reactions can be prevented by prior use of antihistamines and corticosteroids and/or managed by reducing the infusion rate and prompt administration of antihistamines and corticosteroids (see Adverse Reactions section). Rapid infusion should be avoided. Patients should be monitored according to their response, especially liver function, renal function, serum electrolytes, complete blood count and prothrombin reaction time. [Contraindications] This product is contraindicated for patients who are allergic to any of its ingredients. Patients with a history of allergies should only use this product unless their doctor believes that the benefits of using this product outweigh the risks of allergy. [Drug use in pregnant women] Pregnancy fetal teratogenicity (pregnancy-like): There are no reports of pregnant women using this product. In experiments on the reproductive system, rats were given 3 times the recommended human dose, and rabbits were given 3 times the recommended human dose. No evidence of harm to the fetus was found. Because animal reproduction experiments cannot completely predict human reactions and rigorous testing on pregnant women has not been conducted, this product can only be used during pregnancy when the foreseeable benefits outweigh the potential risks to the fetus. Lactating mothers do not know whether this product will be secreted into breast milk. Because of the potential for serious adverse effects of amphotericin in the infant and the importance of the drug to the mother, the nursing mother should make a choice between discontinuing breastfeeding or discontinuing the drug. [Pediatric Use] No unexpected adverse reactions were reported in a pediatric patient with a deep fungal infection who used this product at a dose similar to the adult daily dose (/). [Friendly reminder] 1. All products of our company are original quality inspection reports, certificates, anti-counterfeiting labels, etc. from the original factory. The quality is absolutely reliable and new and old customers are welcome to call us to discuss and order. 2. Our company never provides free samples. Free shipping nationwide. Large quantities can be discounted and shipped on time within hours. Order hotline::! (Yang Dongling) [Specifications] Injections packed in bottles [Packaging] Vials per box [Price description] Yuan/box Yuan/box [Storage] Keep away from temperatures below degrees Celsius Light storage [Manufacturer] American Gidley and Mylan Corporation A total of0articles Related Comments: |